BICYCLE THERAPEUTICS PLC

Oxurion N.V. is a biopharmaceutical enterprise dedicated to the research, development, and marketing of innovative treatments for ocular diseases, operating both within Belgium and across international markets. Its primary commercialized therapy is JETREA, prescribed for vitreomacular adhesion and vitreomacular traction. Beyond this, Oxurion's clinical pipeline includes two promising compounds in Phase II trials for diabetic macular edema (DME): THR-149, which functions as a plasma kallikrein inhibitor, and THR-687, an integrin antagonist. The company also fosters collaborative relationships with Bicycle Therapeutics, INC Research, and Galapagos NV. Founded in 1991, this Leuven, Belgium-headquartered firm adopted its current name, Oxurion N.V., in September 2018, having previously operated as ThromboGenics NV.

C4 Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing innovative therapeutic candidates. Its core strategy involves degrading proteins implicated in disease, addressing a range of conditions including cancer, neurodegenerative disorders, and other illnesses. The company's primary drug candidate, CFT7455, is an orally administered MonoDAC degrader of the IKZF1 and IKZF3 proteins. This compound is currently undergoing Phase 1/2 clinical trials for the treatment of multiple myeloma and various non-Hodgkin lymphomas, such as peripheral T-cell lymphoma and mantle cell lymphoma. Additionally, C4 Therapeutics is advancing several other programs: CFT8634, an orally bioavailable BiDAC degrader targeting the BRD9 protein, for potential use in synovial sarcoma and SMARCB1-deleted solid tumors. CFT1946, an orally administered BiDAC degrader designed to act on the V600X mutant BRAF, aimed at indications like melanoma, non-small cell lung cancer (NSCLC), colorectal cancer, and other solid malignancies. CFT8919, an orally available, allosteric, and mutant-selective BiDAC degrader specifically targeting epidermal growth factor receptor (EGFR) with an L858R mutation in NSCLC. Their early-stage pipeline also features RET degraders for various forms of cancer. C4 Therapeutics, Inc. has formed strategic partnerships with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc., Biogen MA, Inc., and Calico Life Sciences LLC. The company was established in 2015 and its headquarters are located in Watertown, Massachusetts.

Molecular Partners AG0QXX · BiotechSchlieren, Switzerland

68% matchPublic

Molecular Partners AG is a clinical-stage biopharmaceutical company that specializes in the discovery, development, and commercialization of novel therapeutic proteins, leveraging its proprietary DARPin® technology. Its pipeline features several promising candidates: Abicipar, a DARPin-based therapy, is currently undergoing Phase III clinical trials for the management of both neovascular wet age-related macular degeneration (AMD) and diabetic macular edema. MP0420 is a multi-specific DARPin candidate being developed to address the SARS-CoV-2 virus. In the field of oncology, the company is advancing: MP0310, an immuno-oncology agent in Phase Ia trials. MP0317, a tumor-localized immune agonist in Phase I, designed to activate immune cells directly within tumor microenvironments. MP0274, also in Phase I, targeting HER2-positive cancers. Additional programs include MP0423 for COVID-19 treatment, MP0533 as a CD3 T cell candidate for acute myeloid leukemia, and MP0250, engineered to bind to vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and human serum albumin (HSA) to extend its half-life. The company has established significant strategic alliances, notably with Novartis AG for the co-development, manufacturing, and commercialization of DARPin-conjugated radioligand therapies. Other key collaborators include Amgen SA and Allergan, Inc., alongside a discovery partnership with AbbVie Inc. focused on ophthalmology, in addition to various other third-party collaborations. Molecular Partners AG was established in 2004 and has its headquarters in Schlieren, Switzerland.

Nurix Therapeutics, Inc.NRIX · BiotechBrisbane, United States

68% matchPublic

Nurix Therapeutics, Inc., a clinical stage biopharmaceutical company, focuses on the discovery, development, and commercialization of small molecule and antibody therapies for the treatment of cancer, inflammatory conditions, and other diseases. The company develops NX-5948, an orally bioavailable BTK degrader, that is in Phase 2 clinical trials for the treatment of relapsed or refractory B-cell malignancies and autoimmune diseases; NX-2127, an orally bioavailable Bruton’s tyrosine kinase (BTK) degrader, that is in Phase Phase 1a/1b clinical trials for the treatment of relapsed or refractory B-cell malignancies; and NX-1607, an orally bioavailable Casitas B-lineage lymphoma proto-oncogene-B (CBL-B) inhibitor, that is in Phase 1a/1b clinical trials to treat immuno-oncology indications. It is also developing NX-0479/GS-6791, a IRAK4 degrader for the treatment of rheumatoid arthritis and other inflammatory diseases. The company has a strategic collaboration agreement with Gilead Sciences, Inc. (Gilead), Sanofi S.A. (Sanofi), and Pfizer Inc. (Pfizer) for co-development and co-commercialization for multiple drug candidates. The company was formerly known as Nurix Inc. and changed its name to Nurix Therapeutics, Inc. in October 2018. Nurix Therapeutics, Inc. was incorporated in 2009 and is headquartered in Brisbane, California.

Eyebiotech LtdBiotechnologyUnited Kingdom

68% matchPrivate

Eyebiotech Ltd is a clinical-stage biotechnology company headquartered in London, United Kingdom. Founded in 2021, the company focuses on developing novel therapies for ophthalmology and ocular diseases.

Mereo BioPharma Group plc, a London-based biopharmaceutical firm established in 2015, specializes in developing and commercializing innovative therapies for oncology and rare conditions. Operating both in the United Kingdom and internationally, the company boasts a diverse product pipeline. Its primary oncology asset, etigilimab (OMP-313M32), an antibody T-cell immunoreceptor, is presently undergoing Phase 1b clinical investigation for tumor treatment. Another cancer compound, Navicixizumab (OMP-305B83), has already concluded its Phase 1b clinical studies for patients battling late-stage ovarian cancer. Beyond cancer, Mereo is advancing several other promising candidates. These include Acumapimod (BCT-197), a p38 MAP kinase inhibitor, which is currently in Phase II clinical trials for addressing acute exacerbations of chronic obstructive pulmonary disease. Additionally, Leflutrozole (BGS-649), an oral aromatase inhibitor, is being developed to manage hypogonadotropic hypogonadism. Within its rare disease portfolio, Mereo features Setrusumab (BPS-804), a novel antibody designed to treat osteogenesis imperfecta, and Alvelestat (MPH-966), an oral small molecule in Phase II clinical trials for Alpha-1 antitrypsin deficiency. To bolster its research, Mereo BioPharma collaborates with The University of Texas MD Anderson Cancer Center, focusing on the evaluation of its anti-TIGIT therapeutic antibody candidate, etigilimab.