Roivant Sciences

Immunovant, Inc.IMVT · BiotechDurham, United States

78% matchPublic

Immunovant, Inc. is a biopharmaceutical firm in the clinical development phase, dedicated to advancing novel monoclonal antibody therapies for the treatment of various autoimmune conditions. The company's primary focus is batoclimab, a pioneering, fully human monoclonal antibody. This antibody is engineered to specifically target and block the neonatal fragment crystallizable receptor (FcRn), a key mechanism in certain autoimmune diseases. Batoclimab is currently undergoing Phase IIa clinical evaluations for treating both myasthenia gravis and thyroid eye disease. Additionally, it has commenced Phase II clinical studies for patients suffering from warm autoimmune hemolytic anemia. Established in 2018, Immunovant operates from its headquarters in New York, New York, functioning as a subsidiary under the umbrella of Roivant Sciences Ltd.

Akari Therapeutics, Plc is a clinical-stage biotechnology firm dedicated to advancing novel treatments for autoimmune and inflammatory disorders. The company's primary investigational therapy is nomacopan, an advanced, second-generation complement inhibitor. This drug is engineered to counteract both inflammatory and prothrombotic processes. Nomacopan holds promise for a range of serious conditions, including paroxysmal nocturnal hemoglobinuria (PNH), Guillain-Barré syndrome (GBS), hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), and bullous pemphigoid (BP). Akari's operations are headquartered in London, United Kingdom.

Tiziana Life Sciences LtdTLSA · BiotechNew York, United States

67% matchPublic

Tiziana Life Sciences Ltd is a biotechnology firm dedicated to the research and advancement of novel molecular therapies for human ailments, particularly within oncology and immunology. Its flagship immunology program features Foralumab (TZLS-401), a human anti-CD3 monoclonal antibody under development for a range of conditions including Crohn's disease, graft versus host disease, ulcerative colitis, multiple sclerosis, type-1 diabetes, inflammatory bowel disease, psoriasis, and rheumatoid arthritis. Additionally, the company is progressing Milciclib (TZLS-201), a small molecule inhibitor that targets multiple cyclin-dependent, tropomycin receptor, and Src family kinases to suppress abnormal cell growth and cancer progression. Another significant asset is anti-Interleukin 6 receptor (IL6R) mAb (TZLS-501), a fully human monoclonal antibody intended to mitigate IL6-induced inflammation and treat COVID-19 patients. Founded in 1998, Tiziana Life Sciences is based in London, United Kingdom.

Dermata Therapeutics, Inc. operates as a clinical-stage biotechnology enterprise, concentrating its efforts on discovering, advancing, and bringing to market novel pharmaceutical treatments designed to address various medical and cosmetic skin ailments. The company's principal experimental drug, DMT310, has successfully finished Phase IIb clinical trials for moderate-to-severe acne and completed a Phase Ib proof-of-concept study for mild-to-moderate psoriasis. Furthermore, DMT310 is presently undergoing Phase 2 clinical evaluation for moderate-to-severe rosacea. Dermata is also progressing with DMT410, which has concluded Phase Ib proof-of-concept trials aimed at managing hyperhidrosis and other aesthetic concerns. Established in 2014, the firm maintains its headquarters in San Diego, California.

PureTech Health plc operates as a clinical-stage biopharmaceutical enterprise, concentrating its efforts in the United States on the discovery, advancement, and market introduction of novel therapeutic solutions. The company's diverse pipeline targets a wide array of challenging medical conditions, including inflammatory, fibrotic, and immunological disorders, intractable cancers, various lymphatic and gastrointestinal issues, as well as neurological and neuropsychological ailments. Among its significant offerings, PureTech provides KarXT, a treatment designed to modulate muscarinic acetylcholine receptors for managing schizophrenia and the psychosis seen in Alzheimer's disease. Its technological foundations also encompass a regenerative biology platform applicable to conditions like androgenetic alopecia and epithelial aging, alongside an immunomodulation platform dedicated to addressing chronic and acute inflammatory disorders. Additionally, the firm develops oral therapies derived from specific bacterial consortia isolated from the human microbiome and treatments engineered to alleviate cognitive dysfunction associated with depression, multiple sclerosis, post-COVID and ICU recovery, and cancer-related conditions. Further innovations include hematopoietic stem cell-based therapies for individuals with blood cancer, a voice-activated technology platform capable of identifying health-related vocal shifts, and a proprietary system facilitating the oral delivery of biologics, vaccines, and other complex medications. In its robust development pipeline, PureTech is advancing LYT-100 for the treatment of lymphedema and other lymphatic flow anomalies, LYT-200 as an IgG4 monoclonal antibody targeting galectin-9, and LYT-210 for solid tumors. Pioneering technological frameworks under development include Glyph, a synthetic chemistry platform for lymphatic targeting; Orasome technology, which enables oral administration of large molecule therapeutic payloads; a meningeal lymphatics platform with implications for Alzheimer's and Parkinson's diseases; and the Alivio technology platform, designed for inflammation-targeted disease immunomodulation. PureTech Health plc has forged key collaboration and licensing agreements with leading pharmaceutical companies, including Boehringer Ingelheim International GMBH, Eli Lilly and Company, Imbrium Therapeutics L.P., and Shionogi & Co., Ltd. The company was founded in 2015 and maintains its corporate headquarters in Boston, Massachusetts.

Hoth Therapeutics, Inc.BiotechnologyUnited States

66% matchPrivate

Hoth Therapeutics, Inc. is a biopharmaceutical company that advances early-stage pharmaceutical research and development by taking promising drugs through pre-clinical and clinical testing. The company focuses on creating therapeutic treatments across multiple medical areas, including oncology, neurology, inflammatory conditions, and dermatology, with the goal of improving patient quality of life.