Sun Pharma Advanced Research Company Limited

Xenon Pharmaceuticals Inc.XENE · PharmaceuticalsBurnaby, Canada

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Xenon Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company dedicated to discovering and advancing innovative treatments for individuals living with neurological disorders. The company operates primarily from its headquarters in Burnaby, Canada. Its robust clinical pipeline showcases several promising candidates: XEN496, an activator of Kv7 potassium channels, is currently in Phase III clinical trials for KCNQ2 developmental and epileptic encephalopathy. Another Kv7 potassium channel activator, XEN1101, is progressing through Phase II trials, targeting epilepsy and a range of other neurological conditions. The portfolio also includes NBI-921352, a selective inhibitor of the Nav1.6 sodium channel, which is undergoing Phase II clinical evaluation for SCN8A developmental and epileptic encephalopathy, alongside investigations for adult focal epilepsy and other potential indications. Furthermore, XEN007, a central nervous system-acting calcium channel modulator, is also in Phase II development. Beyond its internal development, Xenon Pharmaceuticals has established strategic collaborations. This includes a licensing and development agreement with Neurocrine Biosciences, Inc. focused on epilepsy treatments, and a partnership with Flexion Therapeutics, Inc. to advance PCRX301 (also known as XEN402), a Nav1.7 inhibitor, for post-operative pain management. Established in 1996, the company continues its mission to address significant unmet medical needs in neurology.

SciSparc Ltd. is a pharmaceutical company in the clinical development phase, specializing in creating medications derived from cannabinoid molecules. Their therapeutic pipeline encompasses several key drug candidates: SCI-110, which is being investigated for the treatment of Tourette syndrome, obstructive sleep apnea, and agitation associated with Alzheimer's disease; SCI-160, designed to address pain; and SCI-210, targeting autism spectrum disorder and epilepsy. The company has formed strategic alliances to further its goals. A partnership with Procaps focuses on the development and eventual commercial manufacturing of SCI-110, as well as CannAmide, an oral palmitoylethanolamide in a soft gel capsule. SciSparc is also collaborating with the Sheba Fund for Health Services and Research to explore SCI-210's potential in managing status epilepticus. Additionally, it has teamed up with The Israeli Medical Center for Alzheimer's to conduct a Phase IIa clinical trial, evaluating the safety, tolerability, and effectiveness of SCI-110 for patients experiencing Alzheimer's disease and agitation. Founded in 2004, the company initially operated under the name Therapix Biosciences Ltd. before changing to SciSparc Ltd. in January 2021. Its main corporate office is located in Tel Aviv-Yafo, Israel.

Sumitomo Pharma Co., Ltd. is a global company involved in the creation, production, and sale of a variety of products, including human pharmaceuticals, food ingredients and additives, and veterinary medicines. Its operations span across Japan, North America, China, and other international territories. The company's pharmaceutical offerings address a broad spectrum of medical needs. These include treatments for conditions such as Parkinson's disease, depression, type 2 diabetes, systemic fungal infections, hypertension, pruritus, chronic obstructive pulmonary disease (COPD), angina pectoris, and arrhythmia. Additionally, they manufacture atypical antipsychotics, antiepileptics, carbapenem antibiotics, gastrointestinal products, and specialized medications for Anderson-Fabry disease. Beyond healthcare, Sumitomo Pharma provides food components and enhancement agents like polysaccharides, along with savory flavorings such as soups and bouillons. The company also supplies chemical raw materials, which encompass pharmaceutical excipients, components for personal care products, substances used in coatings and industrial applications, and electronic materials. Moreover, it produces veterinary therapeutic solutions designed for domestic pets, specifically dogs and cats, as well as for various farm animals, including cattle, swine, poultry, horses, and cultivated fish. To drive innovation, Sumitomo Pharma fosters partnerships with several organizations. These collaborators include Healios K.K., Keio University, RIKEN, the Center for iPS Cell Research and Application, Kyoto University, and Aikomi Co., Ltd. The company also maintains a joint development agreement with SanBio Company Limited, a collaboration and license agreement with Otsuka Pharmaceutical Co., Ltd., and a strategic alliance with Roivant Sciences Ltd. Originally established in 1897, the company, headquartered in Osaka, Japan, was known as Sumitomo Dainippon Pharma Co., Ltd. until it adopted its current name, Sumitomo Pharma Co., Ltd., in April 2022. It functions as a subsidiary of Sumitomo Chemical Company, Limited.

LEE'S PHARM00950 · PharmaceuticalsHong Kong, Hong Kong

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Lee's Pharmaceutical Holdings Limited, an investment holding company, develops, manufactures, markets, and sells pharmaceutical products in the People's Republic of China, Hong Kong, and internationally. It focuses on various disease areas, such as cardiovascular, woman's health, pediatrics, rare diseases, oncology, dermatology, and obstetrics. It operates in Proprietary and Generic Products; and Licensed-In Products segments. The Proprietary and Generic Products segment manufactures and sells Nadroparin Calcium injection and Livaracine to treat blood clots and deep vein thrombosis; Yallaferon for viral infection; Slounase for hemostasis; Socazolimab Injection for Recurrent or metastatic cervical cancer; Treprostinil injection for pulmonary arterial hypertension; fondaparinux sodium injection for deep vein thrombosis; and Sodium Phenylbutyrate Granules to treat urea cycle disorders; Apremilast Tablets for Plaque psoriasis; and Azilsartan Tablets for hypertension. The Licensed-In Products segment offers Sancuso for chemotherapy induced nausea and vomiting; Bredinin to treat Immunosuppression in renal transplantation; Centraxal Plus for acute otitis media with tympanostomy tubes; and Ferplex to treat iron deficiency anemia. This segment also offers Intrarosa for vulvovaginal atrophy; Adasuve for agitation associated with schizophrenia or bipolar I disorder in adults; Mictonorm for urinary incontinence; Natulan for Stage III and IV Hodgkin's disease; Lutrate for Prostate cancer; Nitric Oxide for Inhalation for Hypoxic respiratory failure associated with pulmonary hypertension; Omacor to treat Omega-3-acid ethyl esters; Zanidip for hypertension; Readyfusor for post-operative pain management; Teglutik to treat Amyotrophic lateral sclerosis; Trittico for insomnia/depression; Dicoflor and VSL#3 for probiotics; and Zingo for topical local analgesics. The company was founded in 1994 and is headquartered in Sha Tin, Hong Kong.

Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., along with its affiliated entities, is dedicated to the research, development, production, and commercialization of biopharmaceutical products. The company leverages its genetic engineering platform to advance antibody-drug conjugates (ADCs), including CD30-DM1 ADC and Trop2-SN38 ADC, both in Phase I clinical trials for various tumors. Trop2-BB05 ADC is undergoing preclinical evaluation for lung and triple-negative breast cancers, while HER2 ADC has completed preclinical studies for metastatic breast and gastric cancers. Furthermore, Fudan-Zhangjiang utilizes its photodynamic technology platform, featuring hemoporfin in Phase IV clinical trials for port-wine stains, and aminolevulinic acid, which is progressing through Phase II trials for HPV-related cervical conditions and acne, having also finished preclinical investigation for brain gliomas. Its nanotechnology platform is advancing drugs like Nanoparticle Albumin-bound Paclitaxel, undergoing preclinical assessment for oncological applications, and Doxorubicin liposome, also under development for tumors. The firm's expertise in oral solid preparations encompasses obeticholic acid for hepatobiliary and autoimmune disorders; timolol maleate cream, currently in preclinical studies for infantile hemangioma; and the oral formulation FZJ-003, which is in Phase I clinical trials for rheumatoid arthritis and Phase II for atopic dermatitis and ulcerative colitis. Beyond pharmaceuticals, the company is involved in developing both pharmaceutical and medical devices, as well as medical diagnostic solutions and associated services. It also markets everyday consumer goods, clinical laboratory analysis equipment, and relevant software. Additional activities include technology innovation, licensing, consultancy, and promotional efforts, alongside the manufacturing of lyophilized powder injections and active pharmaceutical ingredients (APIs). The company also allocates capital to international medical ventures. Established in 1996, the company operates from its headquarters in Shanghai, People's Republic of China.

Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., together with its associated entities, specializes in the research, development, production, and commercialization of cutting-edge biopharmaceutical products. The company's extensive pipeline is built upon several advanced technological platforms. Its genetic engineering platform prominently features antibody-drug conjugates (ADCs), with candidates like CD30-DM1 ADC and Trop2-SN38 ADC currently undergoing Phase I clinical trials for a range of tumors, including triple-negative breast, bladder, and gastric cancers. Additional ADCs, such as Trop2-BB05 (targeting lung cancer and triple-negative breast cancer) and HER2 ADC (for metastatic breast and gastric cancers), are in pre-clinical development or have completed pre-clinical research. Utilizing its photodynamic technical platform, the company provides hemoporfin, now in Phase IV clinical trials for the treatment of port wine stain. Another key product, aminolevulinic acid, is in Phase II trials for HPV-related cervical diseases and acne, having also completed pre-clinical studies for brain gliomas. Furthermore, Fudan-Zhangjiang employs nanotechnology in its drug development efforts. This includes Nanoparticle Albumin-bound Paclitaxel, which is in pre-clinical studies for various tumors, and a Doxorubicin liposome formulation also under development for oncology applications. The company's oral solid preparation technology platform has yielded obeticholic acid for hepatobiliary and autoimmune diseases. Other developments include timolol maleate cream, in pre-clinical studies for infantile hemangioma, and the FZJ-003 oral preparation, which is in Phase I for rheumatoid arthritis and Phase II for atopic dermatitis and ulcerative colitis. Beyond its core pharmaceutical development, the company is involved in creating pharmaceutical and medical devices, offering medical diagnostic products and related services, and distributing daily necessities, along with clinical laboratory analysis instruments and software. Its activities also encompass technology development, transfer, consulting, and promotion, the manufacture of freeze-dried powder injections and active pharmaceutical ingredients (APIs), and investments in international medical projects. Established in 1996, the company is based in Shanghai, People's Republic of China.